rs11899863

This is a regulatory region variant variant in the THADA gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Elashi AA et al. “Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus.” Bmc Medical Genomics 17(1):115 (2024)

Allele T

OR 0.12

p 2.0e-27

N 6,710,881

Meta-analysisLarge GWAS

multi-ancestry

prostate specific antigen amount

Kachuri L et al. “Genetically adjusted PSA levels for prostate cancer screening.” Nature Medicine 29(6):1412-1423 (2023)

Allele C

OR 0.04

p 2.0e-13

N 95,768

Large GWAS

multi-ancestry

About THADA

This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and apoptosis. [provided by RefSeq, Sep 2016]

View all THADA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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