rs11900673

This is a downstream gene variant variant.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

rheumatoid arthritis

Okada Y et al. “Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.” Nature Genetics 44(5):511-6 (2012)
Allele T
OR 1.11
p 1.0e-8
N 20,965
Meta-analysisLarge GWAS
East Asian
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Research that mentions this SNP (1)

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PLD4 as a novel susceptibility gene for systemic sclerosis in a Japanese population
AssociationN=1,141Chikashi Terao et al.(2013)· Arthritis &amp; Rheumatism

This case-control study identified PLD4 as a novel susceptibility gene for systemic sclerosis (SSc) in a Japanese population, with rs2841277 showing significant association (P=0.00017, OR=1.25). The study also confirmed associations between SSc and rs6932056 in TNFAIP3 (P=0.0000095, OR=1.50) and rs2280381 in IRF8 (P=0.0030, OR=1.26). rs2841280 in PLD4 exon 2 was found in strong linkage disequilibrium with rs2841277 and introduces an amino acid change (E27Q).

Traits studied:Diffuse cutaneous systemic sclerosis (dcSSc)Limited cutaneous systemic sclerosis (lcSSc)Systemic sclerosis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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