rs11902171
This variant is located in the ITGAV gene.
▶Research that mentions this SNP (1)
▶Genetic variants in the integrin gene predicted microRNA-binding sites were associated with the risk of prostate cancerReviewJiaming Liu et al.(2014)· Molecular Carcinogenesis
This review examines how non-coding RNAs (miRNAs and lncRNAs) regulate integrin gene expression in cancer. Several SNPs in integrin genes affect cancer risk through disruption of miRNA binding sites: ITGB3 rs3809865 associates with oral squamous cell carcinoma risk, ITGB4 rs743554 with breast cancer progression, ITGB5 rs2675 with bladder cancer, ITGAV rs11902171 with prostate cancer risk, and ITGA2 rs6898333 and rs6880055 with prostate cancer risk.
About ITGAV
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
View all ITGAV variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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