rs11905235

This variant is located in the ZNF335 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of phospholipid transfer protein in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.11
p 4.0e-16
N 47,745
Large GWAS
European
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ClinVar annotation

Likely Benign★★★☆
7 submitters2 publications

not specified; not provided; Microcephalic primordial dwarfism due to ZNF335 deficiency; Colon adenocarcinoma; Colorectal cancer; Sarcoma; Gastric cancer; Uveal melanoma; Thymoma; Cholangiocarcinoma; Acute myeloid leukemia; Hepatocellular carcinoma; Malignant tumor of esophagus; Nonpapillary renal cell carcinoma; Adrenocortical carcinoma, hereditary; Uterine corpus endometrial carcinoma; Malignant lymphoma, large B-cell, diffuse; Uterine carcinosarcoma; Melanoma; Cervical cancer

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About ZNF335

The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]

View all ZNF335 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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