rs12034
This is a 3 prime utr variant variant in the CXADR gene.
▶Research that mentions this SNP (1)
▶Genome-wide genotype-based risk model for survival in core binding factor acute myeloid leukemia patientsAssociationN=104Silvia Park et al.(2018)· Annals of Hematology
This genome-wide SNP association study in 104 core binding factor acute myeloid leukemia (CBF-AML) patients developed predictive risk models for overall survival (OS) and event-free survival (EFS) incorporating six SNPs each combined with clinical factors. The OS model significantly stratified patients into low- and high-risk groups with 3-year survival rates of 80.4% vs 22.0% (p=8.75×10⁻¹³), while the EFS model achieved 75.0% vs 17.1% (p=5.95×10⁻¹³), demonstrating that genome-wide SNP genotyping can improve survival prediction in CBF-AML beyond conventional clinical factors.
About CXADR
The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
View all CXADR variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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