rs12035879

This is a regulatory region variant variant in the RGS5 gene.

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Research that mentions this SNP (1)

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Genetic variations in regulator of G‐protein signaling (RGS) confer risk of bladder cancer
AssociationN=1,606Eugene K. Lee et al.(2013)· Cancer

Case-control study of 803 bladder cancer patients and 803 healthy controls examining 95 SNPs in 17 RGS (Regulator of G-Protein Signaling) pathway genes. Rs10759 in RGS4 showed the strongest association with reduced bladder cancer risk (OR 0.77, P<0.001), and cumulative analysis of 5 significant SNPs yielded OR 4.13 (95% CI 2.14-7.98) for high-risk genotype combinations. Eleven and thirteen SNPs were associated with recurrence and progression in non-muscle invasive bladder cancer (NMIBC); rs2344673 in RGS5 was most significant for death in muscle-invasive bladder cancer (MIBC), with median survival of 13.3 months vs 81.9 months.

Traits studied:Bladder cancer death/survivalBladder cancer progressionBladder cancer recurrenceBladder cancer riskMuscle-invasive bladder cancer (MIBC)Non-muscle invasive bladder cancer (NMIBC)
PubMedDOIMetascience Observatory

About RGS5

This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022]

View all RGS5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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