rs12075550

This candidate gene association study examined 10 SNPs in addiction-related genes (CNR1, FAAH, DRD2, ANKK1, COMT, OPRM1) in university students and identified the FAAH C385A (rs324420) CC genotype as significantly associated with risky alcohol consumption (p=0.006, OR=2.38). The finding was replicated in an independent sample of 83 participants. Additionally, affective ratings of drug-related pictures were positively correlated with alcohol, tobacco, and cannabis consumption.

This case-control association study examined the FAAH P129T (c.385 C>A) missense mutation in 249 drug-addicted subjects and 785 controls across three ethnic groups. The P129T homozygote genotype showed significant association with multiple drug addiction (P=0.05, OR=2.25 in the case-control study; P=0.00003, OR=3.20 when combined with prior data). Haplotype analysis identified a single ancestral origin and estimated the P129T mutation age at 114,425-177,525 years.