rs1212171
This is a regulatory region variant variant in the NTRK2 gene.
▶Research that mentions this SNP (1)
▶Neurotrophic factor‐related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high‐risk male populationAssociationN=143Conner AC et al.(2008)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A candidate gene association study examined six SNPs in neurotrophic factor genes (NTF3, NTRK2, NTRK3, BDNF, p75NTR) for association with adult ADHD scores in 143 high-risk males from a forensic psychiatric unit. While no SNPs showed significant association after Bonferroni correction, rs6332 in NTF3 exon III showed a trend toward association with increased ADHD scores (P=0.05 for WURS-k; P=0.03 for Wender-Reimherr interview), suggesting the A-allele may be a potential risk factor.
About NTRK2
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
View all NTRK2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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