rs12141569
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
cardiovascular measurement
Kany S et al. “Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk.” Nature Genetics 58(1):47-56 (2026)
Allele C
OR 0.03
p 2.0e-8
N 77,183
Large GWAS
European
aortic stenosis, aortic valve calcification
Thériault S et al. “Genetic Association Analyses Highlight IL6, ALPL, and NAV1 As 3 New Susceptibility Genes Underlying Calcific Aortic Valve Stenosis.” Circulation. Genomic and Precision Medicine 12(10):e002617 (2019)
Allele C
OR 1.15
p 4.0e-8
N 359,187
Large GWAS
European
aortic stenosis
Kany S et al. “Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk.” Nature Genetics 58(1):47-56 (2026)
Allele C
OR 0.03
p 2.0e-17
N 205,483
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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