rs12146713

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GWAS Catalog Trait Associations (13)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

brain attribute

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)
Allele C
OR 34.48
p 1.0e-260
N 33,748
Large GWAS
European
Bahrami S et al. “The genetic landscape of basal ganglia and implications for common brain disorders.” Nature Communications 15(1):8476 (2024)
Allele C
OR —
p 4.0e-12
N 34,794
Large GWAS
European

cerebral cortex area attribute

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)
Allele C
OR 20.53
p 1.0e-93
N 33,748
Large GWAS
European
Shadrin AA et al. “Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.” Neuroimage 244:118603 (2021)
Allele C
OR —
p 1.0e-17
N 35,657
Large GWAS
European

cortical thickness

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)
Allele C
OR 20.38
p 3.0e-92
N 33,748
Large GWAS
European
Shadrin AA et al. “Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.” Neuroimage 244:118603 (2021)
Allele C
OR —
p 1.0e-17
N 35,657
Large GWAS
European

brain connectivity attribute

Sha Z et al. “Genetic architecture of the white matter connectome of the human brain.” Science Advances 9(7):eadd2870 (2023)
Allele T
OR 13.67
p 1.0e-42
N 30,810
Large GWAS
European

thalamus volume

Elvsåshagen T et al. “The genetic architecture of the human thalamus and its overlap with ten common brain disorders.” Nature Communications 12(1):2909 (2021)
Allele C
OR 0.10
p 2.0e-13
N 30,114
Large GWAS
European

lateral ventricle volume measurement

Vojinovic D et al. “Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.” Nature Communications 9(1):3945 (2018)
Allele T
OR 7.28
p 3.0e-13
N 23,533
Large GWAS
multi-ancestry

amygdala volume

Mufford MS et al. “The Genetic Architecture of Amygdala Nuclei.” Biological Psychiatry 95(1):72-84 (2024)
Allele C
OR 1.50
p 4.0e-11
N 31,690
Large GWAS
European

brain volume

Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele C
OR 0.15
p 2.0e-20
N 21,282
Major Consortium StudyLarge GWAS
European

mean fractional anisotropy measurement

Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele C
OR 0.11
p 1.0e-11
N 20,860
Major Consortium StudyLarge GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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