rs12173791

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

endometriosis

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.19
p 5.0e-12
N 314,532
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: A genome‐wide association and polygenic scoring study
Meta-analysisN=3,270Niamh Mullins et al.(2014)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This genome-wide association and polygenic scoring study examined genetic relationships between suicide attempts, suicidal ideation, and major psychiatric disorders across four cohorts (RADIANT n=2,023; GSK-Munich n=807; BACCs n=440; GENDEP n=747). No SNPs reached genome-wide significance in GWAS meta-analyses. Polygenic scores for major depressive disorder significantly predicted suicidal ideation (P=0.015, explaining 1% of variance) and suicide attempts in combined validation dataset (R²=0.3%, P=0.013), suggesting pleiotropy between psychiatric disorders and suicidality. Suicide attempt and ideation appear to have partially independent genetic architectures.

Traits studied:Bipolar disorderMajor depressive disorderSchizophreniaSuicidal ideationSuicide attempt
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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