rs12210271
This is a intron variant variant in the PREP gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
response to angiotensin-converting enzyme inhibitor
Ghouse J et al. “Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci.” European Heart Journal 43(45):4707-4718 (2022)
Allele T
OR 1.13
p 1.0e-19
N 78,000
Large GWAS
European
About PREP
The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. [provided by RefSeq, Jul 2008]
View all PREP variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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