rs12232685
This is a intron variant variant in the LDLRAD4 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
adverse effect, response to xenobiotic stimulus
Tasa T et al. “Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records.” European Journal of Human Genetics : Ejhg 27(3):442-454 (2019)
Allele T
OR 6.99
p 2.0e-8
N 16,226
Large GWAS
European
About LDLRAD4
Enables R-SMAD binding activity. Involved in negative regulation of cell migration; negative regulation of epithelial to mesenchymal transition; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all LDLRAD4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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