rs12257409

This is a intron variant variant in the REEP3 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

lymphocyte count

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.01

p 5.0e-13

N 394,642

Large GWAS

European

aging rate

Roberts V et al. “Genome-Wide Association Study Identifies Genetic Associations with Perceived Age.” The Journal of Investigative Dermatology 140(12):2380-2385 (2020)

Allele C

OR 1.03

p 3.0e-11

N 423,992

Large GWAS

European

About REEP3

Predicted to enable microtubule binding activity. Involved in mitotic nuclear membrane reassembly. Predicted to be located in endoplasmic reticulum; membrane; and microtubule. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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