rs12270054
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
otosclerosis
Rämö JT et al. “Genome-wide screen of otosclerosis in population biobanks: 27 loci and shared associations with skeletal structure.” Nature Communications 14(1):157 (2023)
Allele T
OR 0.75
p 4.0e-20
N 864,702
Large GWAS
European
osteoarthritis, hip
Henkel C et al. “Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement.” Annals of the Rheumatic Diseases 82(3):384-392 (2023)
Allele T
OR 0.92
p 2.0e-10
N 646,831
Meta-analysisLarge GWAS
European
alkaline phosphatase measurement
Chen VL et al. “Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology.” Nature Communications 12(1):816 (2021)
Allele C
OR 5.78
p 8.0e-9
N 390,964
Large GWAS
multi-ancestry
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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