rs12279202

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

interleukin 10 measurement

Fasil Tekola Ayele et al. “Genome-wide associated loci influencing interleukin (IL)-10, IL-1Ra, and IL-6 levels in African Americans” Immunogenetics (2012)
Allele T
OR —
β 0.060
p 4.0e-8
N 704
Small GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genome-wide associated loci influencing interleukin (IL)-10, IL-1Ra, and IL-6 levels in African Americans
AssociationN=707Fasil Tekola Ayele et al.(2012)· Immunogenetics

This genome-wide association study (GWAS) identified genetic variants influencing interleukin levels in African Americans. IL-10 levels showed genome-wide significant associations with 8 SNPs, most notably rs5743185 in PMS1 (p=2.30×10⁻¹⁰), with successful replication of rs17365948 in YWHAZ. IL-1Ra levels showed suggestive associations with SNPs in ASB3 and the IL-1 gene family, with replication of rs4251961. IL-6 levels showed genome-wide significant association with one variant near RP11-314E23.1 (p=8.63×10⁻⁹).

Traits studied:Interleukin-10 (IL-10) levelsInterleukin-1Ra (IL-1Ra) levelsInterleukin-6 (IL-6) levelsPlasma cytokine levels
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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