rs12409639
This is a regulatory region variant variant in the SLC45A3 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
prostate specific antigen amount
▶Research that mentions this SNP (1)
▶Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese populationAssociationN=3,495Sun J. et al.(2013)· Human Genetics
A two-stage GWAS in 3,495 Chinese men (Stage 1: N=1,999; Stage 2: N=1,496) identified three genetic regions associated with prostate-specific antigen (PSA) levels: a novel locus at 1q32.1 (SLC45A3, rs12409639, P=8.43×10⁻¹²) with 20% increase per allele, and two previously reported loci at 10q11.23 (MSMB, rs10993994) and 19q13.33 (KLK3, rs2735839). Combined P-values ranged from 4.62×10⁻¹⁷ to 6.45×10⁻³⁷. The novel SLC45A3 variant was associated with PSA but not prostate cancer risk.
About SLC45A3
Predicted to enable sucrose:proton symporter activity. Predicted to be involved in positive regulation of small molecule metabolic process; regulation of oligodendrocyte differentiation; and sucrose transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all SLC45A3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…