rs12416687
This is a regulatory region variant variant in the AS3MT gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
mean arterial pressure
Simino J et al. “Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.” American Journal of Human Genetics 95(1):24-38 (2014)
Allele T
OR 0.59
p 4.0e-9
N 55,796
Major Consortium StudyLarge GWAS
multi-ancestry
mean corpuscular hemoglobin concentration
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.04
p 2.0e-23
N 583,889
Major Consortium StudyLarge GWAS
multi-ancestry
About AS3MT
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]
View all AS3MT variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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