rs12435797
This variant is located in the NUMB gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
multisite chronic pain
Johnston KJA et al. “Genome-wide association study of multisite chronic pain in UK Biobank.” Plos Genetics 15(6):e1008164 (2019)
Allele G
OR 0.02
p 4.0e-8
N 387,649
Major Consortium StudyLarge GWAS
European
About NUMB
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
View all NUMB variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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