rs12457761
This is a intron variant variant in the RAB27B gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
anxiety disorder
Li W et al. “Genome-wide meta-analysis, functional genomics and integrative analyses implicate new risk genes and therapeutic targets for anxiety disorders.” Nature Human Behaviour 8(2):361-379 (2024)
Allele A
OR 0.93
p 3.0e-10
N 475,216
Meta-analysisLarge GWAS
European
About RAB27B
Enables guanyl ribonucleotide binding activity; myosin V binding activity; and protein domain specific binding activity. Involved in multivesicular body sorting pathway and positive regulation of exocytosis. Located in Golgi stack and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]
View all RAB27B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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