rs12477314

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

forced expiratory volume

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele C
OR 0.02
p 2.0e-20
N 373,397
Large GWAS
European

health trait

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele C
OR 0.01
p 1.0e-12
N 405,979
Large GWAS
European

FEV/FVC ratio, pulmonary function measurement

Soler Artigas M et al. “Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.” Nature Genetics 43(11):1082-90 (2011)
Allele T
OR 0.04
p 2.0e-12
N 48,201
Large GWAS
European

diastolic blood pressure

Surendran P et al. “Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.” Nature Genetics 52(12):1314-1332 (2020)
Allele T
OR 0.10
p 2.0e-9
N 1,164,961
Meta-analysisLarge GWAS
European
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Research that mentions this SNP (1)

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Glutathione‐S‐transferase P1 may predispose children to a decline in pulmonary function after stem cell transplant
AssociationN=49Julie Stark et al.(2017)· Pediatric Pulmonology

A retrospective study of 49 pediatric stem cell transplant patients found that the GSTP1 SNP rs1695 was significantly associated with pulmonary function decline at 1 year post-SCT. Patients homozygous for the ancestral allele (A) showed greater decline in FEV1 (adjusted p<0.01) and FEF25-75 (adjusted p=0.02) compared to those with at least one minor allele (G), suggesting the Val158Met variant may provide protection against post-SCT pulmonary complications.

Traits studied:Bronchiolitis obliteransFEF25-75 declineFEV1 declinePulmonary function after stem cell transplant
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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