rs12553324

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

appendicular lean mass

Pei YF et al. “The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.” Communications Biology 3(1):608 (2020)

Allele C

OR 0.01

p 5.0e-13

N 450,243

Major Consortium StudyLarge GWAS

European

type 2 diabetes mellitus

Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)

Allele G

OR —

p 9.0e-13

N 2,535,601

Large GWAS

multi-ancestry

occupational attainment

Ko H et al. “Genome-wide association study of occupational attainment as a proxy for cognitive reserve.” Brain : a Journal of Neurology 145(4):1436-1448 (2022)

Allele G

OR 0.05

p 3.0e-12

N 248,847

Large GWAS

European

bipolar disorder

Hou L et al. “Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.” Human Molecular Genetics 25(15):3383-3394 (2016)

Allele C

OR 1.12

p 6.0e-9

N 34,950

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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