rs1256062
This is a regulatory region variant variant in the ESR2 gene.
▶Research that mentions this SNP (1)
▶Dietary intake of phytoestrogens, estrogen receptor-beta polymorphisms and the risk of prostate cancerAssociationN=2,096Maria Hedelin et al.(2006)· The Prostate
A Swedish population-based case-control study (CAPS) of 1,314 prostate cancer cases and 782 controls examined interactions between dietary phytoestrogen intake and estrogen receptor-beta (ESR2) gene polymorphisms. Among carriers of the variant C allele at rs2987983 (-13950 T/C), high phytoestrogen intake was associated with substantially reduced prostate cancer risk (OR for highest vs lowest quartile = 0.43, p<0.001), while no association was found in wild-type TT homozygotes. The rs2987983 SNP showed significant gene-environment interaction on both multiplicative (p=0.04) and additive (p=0.04) scales.
About ESR2
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
View all ESR2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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