rs12566888
This variant is located in the PEAR1 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
platelet reactivity efficacy
Verdier H et al. “A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk.” Blood 142(22):1895-1908 (2023)
Allele T
OR 0.12
p 5.0e-24
N 29,806
Large GWAS
European
Downes K et al. “G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1.” Blood Advances 6(7):2319-2330 (2022)
Allele T
OR 0.39
p 3.0e-8
N 1,341
Large GWAS
European
platelet count
Yang Z et al. “Genetic basis of pregnancy-associated decreased platelet counts and gestational thrombocytopenia.” Blood 143(15):1528-1538 (2024)
Allele T
OR 0.09
p 2.0e-21
N 72,816
Large GWAS
East Asian
Thrombocytopenia
Yang Z et al. “Genetic basis of pregnancy-associated decreased platelet counts and gestational thrombocytopenia.” Blood 143(15):1528-1538 (2024)
Allele G
OR 2.00
p 1.0e-15
N 98,189
Large GWAS
East Asian
amount of vascular endothelial growth factor C (human) in blood
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.07
p 4.0e-15
N 47,745
Large GWAS
European
metalloproteinase inhibitor 3 measurement
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.06
p 1.0e-12
N 47,745
Large GWAS
European
platelet aggregation
Chen MH et al. “Exome-chip meta-analysis identifies association between variation in ANKRD26 and platelet aggregation.” Platelets 30(2):164-173 (2019)
Allele A
OR 0.29
p 3.0e-13
N 4,213
Meta-analysis
multi-ancestry
Johnson AD et al. “Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.” Nature Genetics 42(7):608-13 (2010)
Allele A
OR —
p 4.0e-16
N 3,991
Large GWAS
multi-ancestry
About PEAR1
PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008]
View all PEAR1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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