rs12573128
This variant is located in the TCF7L2 gene.
▶Research that mentions this SNP (1)
▶No association between the type 2 diabetes mellitus susceptibility gene, SLC30A8 and schizophrenia in a Chinese populationAssociationN=1,946Xuan Zhang et al.(2012)· Human Psychopharmacology: Clinical and Experimental
A case-control study of 837 schizophrenic patients and 1,109 controls in a Han Chinese population found no significant association between the SLC30A8 rs13266634 (R325W, C/T) polymorphism and schizophrenia risk (χ² = 1.95, p = 0.38 for genotype; χ² = 0.47, p = 0.50 for allele frequencies), nor with any schizophrenia clinical symptoms. This null finding suggests that despite rs13266634 being a robust type 2 diabetes risk variant across multiple GWAS, it does not contribute to the genetic basis of the schizophrenia-T2DM comorbidity.
About TCF7L2
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
View all TCF7L2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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