TCF7L2
transcription factor 7 like 2
Summary
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Known Variants173 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3814570 | 10:114,708,510 | C/T | upstream gene variant | — |
| rs149106073 | 10:114,709,925 | C/T | — | benign |
| rs77172590 | 10:114,710,019 | G/T | — | benign |
| rs76088094 | 10:114,710,560 | C/T | — | benign |
| rs2134177455 | 10:114,710,597 | G/C | — | uncertain significance |
| rs373425129 | 10:114,710,599 | G/A | — | likely benign |
| rs199669957 | 10:114,710,665 | T/A | — | uncertain significance |
| rs78277257 | 10:114,710,876 | C/G | — | — |
| rs373536721 | 10:114,710,976 | G/A | — | uncertain significance |
| rs1589562806 | 10:114,710,995 | A/G | — | likely benign |
| rs766204038 | 10:114,711,273 | G/T | — | uncertain significance |
| rs753753787 | 10:114,711,281 | C/A | — | uncertain significance |
| rs143305771 | 10:114,711,333 | C/T | — | likely benign |
| rs1589569370 | 10:114,711,376 | T/C | — | likely benign |
| rs555488416 | 10:114,711,394 | C/A | — | benign |
| rs113999985 | 10:114,711,677 | C/T | — | benign |
| rs7094463 | 10:114,711,983 | A/G | regulatory region variant | — |
| rs7094871 | 10:114,712,154 | C/T | — | — |
| rs6585194 | 10:114,717,471 | C/G | regulatory region variant | — |
| rs11196170 | 10:114,722,621 | G/C | — | — |
| rs368705098 | 10:114,724,330 | G/A | — | uncertain significance |
| rs750762501 | 10:114,724,342 | T/C | — | uncertain significance |
| rs780519218 | 10:114,724,349 | C/T | — | uncertain significance |
| rs11196171 | 10:114,724,473 | A/G | — | benign |
| rs113353253 | 10:114,724,498 | A/G | — | benign |
| rs866915832 | 10:114,724,537 | A/G | — | benign |
| rs7068313 | 10:114,725,926 | C/T | intron variant | — |
| rs11196172 | 10:114,726,843 | G/C | — | — |
| rs11196173 | 10:114,727,067 | C/A | — | — |
| rs12573128 | 10:114,730,797 | A/T | — | — |
| rs190373810 | 10:114,731,360 | C/T | intron variant | — |
| rs7917983 | 10:114,732,882 | T/G | — | — |
| rs11196174 | 10:114,734,096 | A/T | — | — |
| rs11196175 | 10:114,736,614 | T/G | — | — |
| rs114322470 | 10:114,736,670 | T/G | intron variant | — |
| rs117229942 | 10:114,737,777 | C/T | intron variant | — |
| rs184509201 | 10:114,740,337 | C/G | intron variant | — |
| rs190552429 | 10:114,742,469 | C/T | upstream gene variant | — |
| rs7895307 | 10:114,743,961 | A/G | upstream gene variant | — |
| rs4073980 | 10:114,746,580 | C/G | upstream gene variant | — |
| rs181345902 | 10:114,747,513 | C/G | coding sequence variant | — |
| rs4074718 | 10:114,748,617 | G/A | regulatory region variant | — |
| rs75933965 | 10:114,749,421 | G/A | downstream gene variant | — |
| rs35011184 | 10:114,749,734 | G/A | downstream gene variant | — |
| rs17747324 | 10:114,752,503 | T/C | downstream gene variant | — |
| rs61875120 | 10:114,753,259 | T/C | intron variant | — |
| rs34872471 | 10:114,754,071 | T/C | intron variant | — |
| rs7901695 | 10:114,754,088 | T/C | intron variant | — |
| rs4506565 | 10:114,756,041 | A/G | — | — |
| rs7903146 | 10:114,758,349 | C/T | intron variant | risk factor |
| rs7092484 | 10:114,760,933 | G/A | regulatory region variant | — |
| rs4132670 | 10:114,767,771 | G/A | intron variant | — |
| rs6585201 | 10:114,768,783 | G/A | intron variant | — |
| rs55899248 | 10:114,773,608 | A/G | intron variant | — |
| rs12244851 | 10:114,773,926 | T/C | — | benign |
| rs7904519 | 10:114,773,927 | A/G | intron variant | benign |
| rs7918599 | 10:114,777,396 | C/T | — | benign |
| rs111824940 | 10:114,777,657 | G/A | — | benign |
| rs10885405 | 10:114,777,670 | C/T | — | benign |
| rs10885406 | 10:114,777,724 | A/G | intron variant | benign |
| rs112110856 | 10:114,784,602 | C/T | intron variant | — |
| rs7074440 | 10:114,785,424 | G/A | intron variant | benign |
| rs7924080 | 10:114,787,012 | T/G | — | — |
| rs56299331 | 10:114,788,436 | C/T | intron variant | — |
| rs12243326 | 10:114,788,815 | T/C | regulatory region variant | — |
| rs148288814 | 10:114,789,545 | C/T | intron variant | — |
| rs72826093 | 10:114,793,595 | G/A | intron variant | — |
| rs140658764 | 10:114,793,907 | T/C | intron variant | — |
| rs4367880 | 10:114,795,256 | G/T | — | — |
| rs377724519 | 10:114,799,778 | C/T | — | likely benign |
| rs1396649788 | 10:114,799,813 | T/G | — | uncertain significance |
| rs1390561716 | 10:114,799,852 | G/C | — | uncertain significance |
| rs1023635345 | 10:114,799,860 | G/A | — | uncertain significance |
| rs140603697 | 10:114,799,861 | G/A | — | likely benign |
| rs143077353 | 10:114,799,880 | A/G | — | likely benign |
| rs7895340 | 10:114,801,525 | G/A | intron variant | — |
| rs11196205 | 10:114,807,047 | G/C | regulatory region variant | risk factor |
| rs12255372 | 10:114,808,902 | G/T | intron variant | risk factor |
| rs112694314 | 10:114,828,594 | T/C | intron variant | — |
| rs3829909 | 10:114,831,434 | A/T | regulatory region variant | — |
| rs3750804 | 10:114,833,850 | C/T | regulatory region variant | — |
| rs145003494 | 10:114,834,411 | G/T | — | — |
| rs61872795 | 10:114,835,674 | C/T | intron variant | — |
| rs12251238 | 10:114,837,263 | C/T | intron variant | — |
| rs11196218 | 10:114,840,494 | G/A | intron variant | — |
| rs1018211508 | 10:114,849,214 | C/T | — | uncertain significance |
| rs368446452 | 10:114,849,301 | T/A | — | uncertain significance |
| rs10749127 | 10:114,849,353 | C/T | intron variant | benign |
| rs4917644 | 10:114,849,399 | T/C | — | benign |
| rs11196224 | 10:114,855,397 | C/G | — | — |
| rs533001396 | 10:114,858,211 | A/G | — | — |
| rs7085532 | 10:114,859,463 | G/A | regulatory region variant | — |
| rs193023456 | 10:114,871,695 | G/A | regulatory region variant | — |
| rs290475 | 10:114,874,019 | C/A | — | — |
| rs74157220 | 10:114,877,867 | G/T | intron variant | — |
| rs12772424 | 10:114,880,551 | A/T | intron variant | — |
| rs143876660 | 10:114,881,845 | A/G | intron variant | — |
| rs880082 | 10:114,889,261 | T/A | intron variant | — |
| rs7898108 | 10:114,900,627 | C/T | — | benign |
| rs2136838531 | 10:114,900,942 | G/A | — | pathogenic |
Showing 100 of 173 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.