rs75933965
This is a downstream gene variant variant in the TCF7L2 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
diabetes mellitus
Schoeler T et al. “Participation bias in the UK Biobank distorts genetic associations and downstream analyses.” Nature Human Behaviour 7(7):1216-1227 (2023)
Allele A
OR 0.01
p 8.0e-25
N 283,227
Major Consortium StudyLarge GWAS
European
periodontitis
Yu YH et al. “Candidate loci shared among periodontal disease, diabetes and bone density.” Frontiers in Endocrinology 13:1016373 (2022)
Allele A
OR 0.05
p 6.0e-13
N 506,596
Large GWAS
About TCF7L2
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
View all TCF7L2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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