rs34872471
This is a intron variant variant in the TCF7L2 gene.
▶GWAS Catalog Trait Associations (35)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (35)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
▶Research that mentions this SNP (1)
▶Genome‐wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African AmericansAssociationN=6,224Jacob M. Keaton et al.(2018)· Genetic Epidemiology
This genome-wide interaction analysis in 6,224 African Americans identified CMIP rs17197883 as a novel type 2 diabetes susceptibility locus through interaction with the insulin secretion variant MTNR1B rs10830963. The CMIP variant showed antagonistic interaction (P_INTXN = 1.43×10^-8) with opposite effects depending on MTNR1B carrier status: OR = 2.29 (95% CI 1.59-3.28) in AIRg-lowering allele carriers vs. OR = 0.78 (95% CI 0.67-0.90) in non-carriers.
About TCF7L2
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
View all TCF7L2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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