rs34872471
This is a intron variant variant in the TCF7L2 gene.
▶GWAS Catalog Trait Associations (35)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (35)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
type 2 diabetes mellitus
Elashi AA et al. “Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus.” Bmc Medical Genomics 17(1):115 (2024)
Allele C
OR 0.29
p —
N 6,710,881
Meta-analysisLarge GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.30
p 1.0e-234
N 667,504
Large GWAS
multi-ancestry
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.23
p 9.9e-324
N 612,947
Major Consortium StudyLarge GWAS
multi-ancestry
Vujkovic M et al. “Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.” Nature Genetics 52(7):680-691 (2020)
Allele C
OR 0.29
p 1.0e-49
N 216,287
Meta-analysisLarge GWAS
East Asian, South Asian
Cook JP et al. “Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility.” European Journal of Human Genetics : Ejhg 24(8):1175-80 (2016)
Allele C
OR 1.31
p 6.0e-53
N 71,604
Large GWAS
multi-ancestry
Bonàs-Guarch S et al. “Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.” Nature Communications 9(1):321 (2018)
Allele C
OR 1.42
p 1.0e-94
N 70,127
Large GWAS
European
Petty LE et al. “Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.” Nature Communications 16(1):3438 (2025)
Allele C
OR 0.78
p 3.0e-46
N 60,975
Large GWAS
Hispanic or Latin American
Guindo-Martínez M et al. “The impact of non-additive genetic associations on age-related complex diseases.” Nature Communications 12(1):2436 (2021)
Allele C
OR 1.36
p 1.0e-52
N 56,637
Large GWAS
European
Imamura M et al. “Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.” Nature Communications 7:10531 (2016)
Allele C
OR 1.43
p 3.0e-23
N 41,646
Large GWAS
multi-ancestry
diabetes mellitus
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.26
p 9.9e-324
N 404,034
Major Consortium StudyLarge GWAS
multi-ancestry
diabetes mellitus, Drugs used in diabetes use measurement
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.26
p 9.9e-324
N 315,668
Major Consortium StudyLarge GWAS
European
glucose measurement
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.12
p 9.9e-324
N 601,111
Major Consortium StudyLarge GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.05
p 3.0e-85
N 448,252
Large GWAS
multi-ancestry
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele T
OR 0.04
p 3.0e-17
N 114,870
Large GWAS
European
Davyson E et al. “Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids.” Biological Psychiatry 94(8):630-639 (2023)
Allele T
OR 0.04
p 1.0e-16
N 88,174
Large GWAS
European
Jacobs BM et al. “Genetic architecture of routinely acquired blood tests in a British South Asian cohort.” Nature Communications 15(1):8929 (2024)
Allele T
OR 0.07
p 9.0e-11
N 38,000
Large GWAS
South Asian
HbA1c measurement
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.15
p 9.9e-324
N 492,335
Major Consortium StudyLarge GWAS
multi-ancestry
Jacobs BM et al. “Genetic architecture of routinely acquired blood tests in a British South Asian cohort.” Nature Communications 15(1):8929 (2024)
Allele T
OR 0.07
p 5.0e-17
N 38,000
Large GWAS
South Asian
diabetic retinopathy
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.30
p 3.0e-261
N 432,209
Major Consortium StudyLarge GWAS
European
Xue Z et al. “Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank.” Ebiomedicine 82:104161 (2022)
Allele T
OR 0.29
p 4.0e-15
N 62,229
Meta-analysisMajor Consortium StudyLarge GWAS
European
diabetic eye disease
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.30
p 2.0e-248
N 431,357
Major Consortium StudyLarge GWAS
European
body mass index
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.07
p 3.0e-121
N 424,231
Major Consortium StudyLarge GWAS
European
Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)
Allele T
OR 0.03
p 9.0e-9
N 98,277
Large GWAS
multi-ancestry
type 2 diabetes nephropathy
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.22
p 5.0e-116
N 439,106
Major Consortium StudyLarge GWAS
European
blood glucose amount
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele T
OR 0.05
p 1.0e-105
N 928,679
Large GWAS
multi-ancestry
▶Research that mentions this SNP (1)
▶Genome‐wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African AmericansAssociationN=6,224Jacob M. Keaton et al.(2018)· Genetic Epidemiology
Genome‐wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans
AssociationN=6,224Jacob M. Keaton et al.(2018)· Genetic Epidemiology
This genome-wide interaction analysis in 6,224 African Americans identified CMIP rs17197883 as a novel type 2 diabetes susceptibility locus through interaction with the insulin secretion variant MTNR1B rs10830963. The CMIP variant showed antagonistic interaction (P_INTXN = 1.43×10^-8) with opposite effects depending on MTNR1B carrier status: OR = 2.29 (95% CI 1.59-3.28) in AIRg-lowering allele carriers vs. OR = 0.78 (95% CI 0.67-0.90) in non-carriers.
Traits studied:Acute insulin response to glucoseFasting glucoseType 2 diabetes
About TCF7L2
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
View all TCF7L2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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