rs12576775

This variant is located in the TENM4 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

bipolar disorder

Ikeda M et al. “A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder.” Molecular Psychiatry 23(3):639-647 (2018)
Allele G
OR 1.18
p 3.0e-9
N 81,582
Large GWAS
multi-ancestry
“Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.” Nature Genetics 43(10):977-83 (2011)
Allele G
OR 1.14
p 4.0e-8
N 16,731
Large GWAS
European
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Research that mentions this SNP (1)

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Neurophysiologic effect of GWAS derived schizophrenia and bipolar risk variants
FunctionalN=273Mei‐Hua Hall et al.(2014)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This functional study investigated neurophysiologic effects of genome-wide association study (GWAS)-derived schizophrenia (SCZ) and bipolar disorder (BPD) risk variants in 199 patients with psychotic illness and 74 healthy controls. The SCZ risk allele (G) at TCF4 rs17512836 showed significant association with reduced auditory P3 amplitude (P=0.00017) and delayed P3 latency (P=0.005), suggesting a mechanism involving compromised attention and working memory capacity in psychotic disorders.

Traits studied:Bipolar disorderN1 amplitudeP2 amplitudeP3 amplitudeP3 latencyP50 sensory gatingPsychosisSchizophrenia
PubMedDOIMetascience Observatory

About TENM4

The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]

View all TENM4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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