rs12587257

This variant is located in the FNTB gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

erythrocyte count

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.02

p 1.0e-25

N 503,987

Large GWAS

multi-ancestry

grip strength measurement

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)

Allele A

OR 0.01

p 1.0e-8

N 404,112

Large GWAS

European

About FNTB

Enables acetyltransferase activator activity; enzyme binding activity; and zinc ion binding activity. Contributes to protein farnesyltransferase activity. Involved in protein farnesylation and regulation of microtubule-based movement. Part of microtubule associated complex and protein farnesyltransferase complex. Implicated in anxiety disorder. [provided by Alliance of Genome Resources, Jul 2025]

View all FNTB variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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