rs12597563

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

heart failure

Henry A et al. “Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.” Nature Genetics 57(4):815-828 (2025)
Allele C
OR 0.04
p 1.0e-9
N 1,968,806
Meta-analysisLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genome-wide Association Studies Reveal Novel Locus With Sex-/Therapy-Specific Fracture Risk Effects in Childhood Cancer Survivors
Meta-analysisN=3,870Cindy Im et al.(2020)· Journal of Bone and Mineral Research

Genome-wide association study of fracture risk in childhood cancer survivors identified a novel female-specific locus at 16p13.3 (HAGHL) with rs1406815 showing genome-wide significant association (HR=1.43, P=8.2×10^-9) in combined discovery (N=2,453 CCSS) and replication (N=1,417 SJLIFE) cohorts. Effects were markedly amplified by head/neck radiation therapy dose. A second locus at CD86 (3q13.33) reached significance in discovery but did not replicate.

Traits studied:Fracture risk in childhood cancer survivorsIncident fractures after cancer diagnosis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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