rs12611091
This is a intron variant variant in the BRSK1 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
estradiol measurement
Oppenheimer H et al. “No causal links between estradiol and female's brain and mental health using Mendelian randomization.” Nature Communications 16(1):10915 (2025)
Allele C
OR 1.06
p 2.0e-9
N 207,119
Large GWAS
European
About BRSK1
Enables magnesium ion binding activity and protein serine/threonine kinase activity. Involved in mitotic G2 DNA damage checkpoint signaling and protein phosphorylation. Acts upstream of or within G2/M transition of mitotic cell cycle; peptidyl-serine phosphorylation; and response to UV. Located in cell junction; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
View all BRSK1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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