rs12615970
This variant is located in the ALLC gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
diabetic nephropathy
Salem RM et al. “Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.” Journal of the American Society of Nephrology : Jasn 30(10):2000-2016 (2019)
Allele A
OR 1.32
p 9.0e-9
N 19,104
Large GWAS
European
glomerular filtration rate
Sandholm N et al. “Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.” Diabetologia 65(9):1495-1509 (2022)
Allele A
OR 1.31
p 9.0e-9
N 26,212
Meta-analysisLarge GWAS
European
About ALLC
Allantoicase (EC 3.5.3.4) participates in the uric acid degradation pathway. Its enzymatic activity, like that of urate oxidase (MIM 191540), was lost during vertebrate evolution.[supplied by OMIM, Nov 2008]
View all ALLC variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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