rs12659258
This is a intron variant variant in the UGT3A1 gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
X-24544 measurement
Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele A
OR 0.65
p 6.0e-255
N 7,939
Large GWAS
European
GlcNAc sulfate conjugate of C21H34O2 steroid measurement
Yin X et al. “Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.” Nature Communications 13(1):1644 (2022)
Allele A
OR 0.78
p 2.0e-76
N 6,136
Large GWAS
European
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) measurement
Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele A
OR 0.28
p 2.0e-38
N 8,028
Large GWAS
European
5alpha-pregnan-3beta,20beta-diol monosulfate (1) measurement
Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)
Allele A
OR 0.30
p 2.0e-35
N 5,863
Large GWAS
multi-ancestry
5alpha-pregnan-diol disulfate measurement
Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)
Allele A
OR 0.18
p 9.0e-12
N 4,514
Large GWAS
multi-ancestry
About UGT3A1
Enables glucuronosyltransferase activity. Part of UDP-N-acetylglucosamine transferase complex. [provided by Alliance of Genome Resources, Jul 2025]
View all UGT3A1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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