rs12712127

This is a intron variant variant in the IL1R1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

circulating fibrinogen levels

Sabater-Lleal M et al. “Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.” Circulation 128(12):1310-24 (2013)

Allele A

OR 0.01

p 3.0e-8

N 91,323

Meta-analysisLarge GWAS

multi-ancestry

About IL1R1

This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]

View all IL1R1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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