rs12722502

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

asthma

Han Y et al. “Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.” Nature Communications 11(1):1776 (2020)

Allele C

OR 1.27

p 1.0e-24

N 303,859

Large GWAS

European

Zhou W et al. “Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.” Cell Genomics 2(10):100192 (2022)

Allele C

OR 0.13

p 4.0e-10

N 1,800,785

Meta-analysisLarge GWAS

multi-ancestry

Olafsdottir TA et al. “Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis.” Nature Communications 11(1):393 (2020)

Allele C

OR 1.24

p 1.0e-17

N 771,388

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele C

OR 0.21

p 1.0e-9

N 625,448

Large GWAS

multi-ancestry

Valette K et al. “Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank.” Communications Biology 4(1):700 (2021)

Allele C

OR 0.20

p 1.0e-15

N 408,422

Major Consortium StudyLarge GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.24

p 2.0e-18

N 394,626

Large GWAS

European

Zhu Z et al. “Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.” The European Respiratory Journal 54(6) (2019)

Allele C

OR 1.22

p 6.0e-17

N 394,283

Large GWAS

multi-ancestry

Ferreira MAR et al. “Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.” American Journal of Human Genetics 104(4):665-684 (2019)

Allele C

OR 1.25

p 2.0e-18

N 341,215

Large GWAS

European

eosinophil count

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.07

p 2.0e-18

N 394,642

Large GWAS

European

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele T

OR 0.07

p 1.0e-17

N 408,112

Large GWAS

European

Eczematoid dermatitis, allergic rhinitis

Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)

Allele C

OR 1.23

p 3.0e-18

N 323,807

Major Consortium StudyLarge GWAS

European

childhood onset asthma

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele T

OR 0.21

p 1.0e-8

N 601,193

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs12722502

GWAS Catalog Trait Associations (4)

asthma

eosinophil count

Eczematoid dermatitis, allergic rhinitis

childhood onset asthma

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