rs12740484

This is a intron variant variant in the SIPA1L2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele A

OR 0.01

p 5.0e-14

N 3,382,012

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

About SIPA1L2

This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]

View all SIPA1L2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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