rs12843772
This variant is located in the ZIC3 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
neuroimaging measurement
Jiang Z et al. “The X chromosome's influences on the human brain.” Science Advances 11(4):eadq5360 (2025)
Allele T
OR 8.68
p 4.0e-18
N 37,772
Large GWAS
European
brain volume
Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele T
OR 0.04
p 2.0e-8
N 21,282
Major Consortium StudyLarge GWAS
European
total cortical area measurement
Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele T
OR 0.05
p 2.0e-11
N 21,282
Major Consortium StudyLarge GWAS
European
▶ClinVar annotation
Benign★☆☆☆
1 submitterAbout ZIC3
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]
View all ZIC3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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