rs12924912

This variant is located in the PRSS22 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

brain-specific serine protease 4 measurement

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)

Allele T

OR 0.29

p 3.0e-24

N 2,935

Large GWAS

Greater Middle Eastern (Middle Eastern, North African or Persian)

About PRSS22

This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]

View all PRSS22 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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