rs12927320
This variant is located in the MARVELD3 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
sexual activity behaviour attribute
Zietsch BP et al. “Genomic evidence consistent with antagonistic pleiotropy may help explain the evolutionary maintenance of same-sex sexual behaviour in humans.” Nature Human Behaviour 5(9):1251-1258 (2021)
Allele C
OR 0.11
p 4.0e-8
N 358,426
Large GWAS
European
About MARVELD3
Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in bicellular tight junction assembly. Acts upstream of or within several processes, including negative regulation of JNK cascade; negative regulation of epithelial cell migration; and protein localization to cell junction. Located in bicellular tight junction and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]
View all MARVELD3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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