rs1294421

This is a intergenic variant variant in the LOC101928004 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

FEV/FVC ratio

Jackson VE et al. “Meta-analysis of exome array data identifies six novel genetic loci for lung function.” Wellcome Open Research 3:4 (2018)

Allele T

OR 9.81

p 1.0e-22

N 68,470

Meta-analysisLarge GWAS

multi-ancestry

waist-hip ratio

Heid IM et al. “Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.” Nature Genetics 42(11):949-60 (2010)

Allele G

OR —

β 0.030

p 2.0e-17

N 77,167

Meta-analysisLarge GWAS

European

Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)

Allele G

OR 0.03

p 7.0e-14

N 143,480

Large GWAS

multi-ancestry

Berndt SI et al. “Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.” Nature Genetics 45(5):501-12 (2013)

Allele G

OR 1.16

p 2.0e-10

N 10,255

Meta-analysisLarge GWAS

European

Inguinal hernia

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.09

p 4.0e-15

N 623,807

Large GWAS

multi-ancestry

Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)

Allele G

OR 1.08

p 2.0e-10

N 275,546

Major Consortium StudyLarge GWAS

European

Ahmed WU et al. “Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes.” Plos One 17(12):e0272261 (2022)

Allele G

OR 1.07

p 6.0e-10

N 112,746

Meta-analysisLarge GWAS

European

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Research that mentions this SNP (2)

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Association of the LINGO2-related SNP rs10968576 with body mass in a cohort of elderly Swedes

AssociationN=949Mathias Rask-Andersen et al.(2015)· Molecular Genetics and Genomics

Association study of 35 GWAS-identified body mass SNPs in 949 elderly Swedish participants (mean age 70-75 years). Significant association found between rs10968576 (LINGO2, intron 4) and BMI with a larger effect size (β = 0.69 kg/m²) than reported in younger populations, suggesting age-specific genetic effects on body mass in the elderly.

Traits studied:Body Mass IndexBody adiposityObesityOverweight

PubMed DOI Metascience Observatory

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Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals

AssociationN=6,039Burgdorf KS et al.(2012)· Diabetologia

This association study investigates 18 BMI-associated and 14 WHR-associated gene variants identified by prior GWAS in 6,039 Danish individuals from the Inter99 cohort. The study found that QPCTL rs2287019 C allele was associated with increased insulinogenic index (7.4%, p=4.0×10⁻⁷) and disposition index (5.6%, p=6.4×10⁻⁵), while LRP1B rs2890652 C allele was associated with insulin resistance (3.3% increase in HOMA-IR, p=0.0011). For WHR variants, LYPLAL1/SLC30A10 rs4846567 G allele carriers showed improved insulin sensitivity (5.2% lower HOMA-IR in women, p=0.00086), whereas VEGFA rs6905288 A allele carriers showed insulin resistance in women (3.7% increase in HOMA-IR, p=0.00036).

Traits studied:BIGTT-AIR (Beta Cell Function)Body Mass Index (BMI)Disposition IndexFasting Plasma GlucoseFasting Serum InsulinHOMA-IR (Insulin Resistance)Insulinogenic IndexMatsuda Index (Insulin Sensitivity)Waist-Hip Ratio (WHR)

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs1294421

GWAS Catalog Trait Associations (3)

FEV/FVC ratio

waist-hip ratio

Inguinal hernia

Research that mentions this SNP (2)

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