rs12945870

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele T

OR 0.01

p 6.0e-26

N 2,669,029

Large GWAS

European

red blood cell density

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)

Allele T

OR —

p 9.0e-25

N 727,624

Large GWAS

multi-ancestry

platelet count

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.03

p 2.0e-17

N 583,459

Major Consortium StudyLarge GWAS

multi-ancestry

hemoglobin measurement

Oskarsson GR et al. “Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis.” Communications Biology 3(1):189 (2020)

Allele C

OR —

β 0.016

p 1.0e-13

N 684,122

Large GWAS

European

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele C

OR 0.02

p 2.0e-10

N 172,925

Large GWAS

European

bitter alcoholic beverage consumption measurement

Zhong VW et al. “A genome-wide association study of bitter and sweet beverage consumption.” Human Molecular Genetics 28(14):2449-2457 (2019)

Allele T

OR 0.01

p 2.0e-8

N 336,448

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs12945870

GWAS Catalog Trait Associations (5)

smoking initiation

red blood cell density

platelet count

hemoglobin measurement

bitter alcoholic beverage consumption measurement

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