rs12964116

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

allergic disease

Ferreira MAR et al. “Age-of-onset information helps identify 76 genetic variants associated with allergic disease.” Plos Genetics 16(6):e1008725 (2020)
Allele G
OR 0.11
p 5.0e-23
N 477,968
Large GWAS
European

allergic disease, age at onset

Ferreira MAR et al. “Age-of-onset information helps identify 76 genetic variants associated with allergic disease.” Plos Genetics 16(6):e1008725 (2020)
Allele G
OR 0.11
p 6.0e-23
N 117,130
Large GWAS
European

childhood onset asthma

Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)
Allele G
OR 1.34
p 3.0e-16
N 327,670
Large GWAS
European

asthma

Valette K et al. “Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank.” Communications Biology 4(1):700 (2021)
Allele G
OR 0.11
p 1.0e-9
N 408,422
Major Consortium StudyLarge GWAS
European
Han Y et al. “Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.” Nature Communications 11(1):1776 (2020)
Allele G
OR —
p 2.0e-8
N 536,345
Large GWAS
multi-ancestry
Zhu Z et al. “Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.” The European Respiratory Journal 54(6) (2019)
Allele G
OR 1.10
p 2.0e-9
N 394,283
Large GWAS
multi-ancestry
Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)
Allele G
OR —
p 4.0e-9
N 281,699
Major Consortium StudyLarge GWAS
European
Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)
Allele G
OR 1.92
p 5.0e-8
N 37,846
Large GWAS
European

food allergy measurement

Marenholz I et al. “Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy.” Nature Communications 8(1):1056 (2017)
Allele G
OR 1.90
p 2.0e-8
N 2,884
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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