rs12964619

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neurotrophin-3 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.04
p 3.0e-12
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans
AssociationN=2,089Caitrin W. McDonough et al.(2009)· Human Genetics

A case-control genetic association study in 1,025 African American type 2 diabetes-associated end-stage renal disease (DM-ESRD) cases and 1,064 controls identified associations with diabetic nephropathy risk in the CNDP1 and CNDP2 carnosinase genes on chromosome 18q22.3-23. rs6566810 (CNDP2) showed recessive-model association with DM-ESRD (p=0.0015, OR 2.29), rs4892247 (CNDP1) was protective (p=0.0146, OR 0.73), and multiple haplotypes showed stronger associations, particularly among non-5L-5L individuals, suggesting that the protective effect of the 5L-5L repeat genotype may be masked by risk haplotypes.

Traits studied:Diabetic nephropathyType 2 diabetes-associated end-stage renal disease (DM-ESRD)
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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