rs13092160
This is a upstream gene variant variant in the CCR3 gene.
▶Research that mentions this SNP (1)
▶Two-stage association study in Chinese Han identifies two independent associations in CCR1/CCR3 locus as candidate for Behçet’s disease susceptibilityAssociationN=2,338Shengping Hou et al.(2012)· Human Genetics
A two-stage association study in Chinese Han population identified multiple independent SNPs in the CCR1/CCR3 locus associated with Behçet's disease susceptibility. Three SNPs (rs13084057, rs13092160, rs13075270) showed consistent association across both stages with combined P-values ranging from 2.76×10⁻⁷ to 6.50×10⁻⁸ and odds ratios of 0.28-0.32, indicating protective effects. SNP rs13092160 was identified as an eQTL variant affecting CCR1 and CCR3 gene expression.
About CCR3
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
View all CCR3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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