rs13106616
This is a upstream gene variant variant in the LOC101928622 gene.
▶Research that mentions this SNP (1)
▶Genome-wide Interrogation of Germline Genetic Variation Associated With Treatment Response in Childhood Acute Lymphoblastic LeukemiaAssociationN=487Yang JJ et al.(2009)· JAMA
Genome-wide Interrogation of Germline Genetic Variation Associated With Treatment Response in Childhood Acute Lymphoblastic Leukemia
AssociationN=487Yang JJ et al.(2009)· JAMA
Genome-wide association study of childhood acute lymphoblastic leukemia (ALL) treatment response identifying 102 SNPs associated with minimal residual disease (MRD) in two independent cohorts (P ≤ 0.0125), including 5 SNPs in the IL15 gene (rs17007695, P=8.8×10⁻⁷). Twenty-one SNPs associated with both hematologic relapse and antileukemic drug clearance, linking MRD eradication to drug disposition.
Traits studied:Acute lymphoblastic leukemia (ALL)Drug pharmacokinetics (etoposide clearance, methotrexate clearance)Early response to therapyHematologic relapseMinimal residual disease (MRD)
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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