rs13141641
This is a intergenic variant variant.
▶GWAS Catalog Trait Associations (10)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (10)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
FEV/FVC ratio
Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)
Allele T
OR 0.07
p 4.0e-184
N 321,047
Large GWAS
European
peak expiratory flow
Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)
Allele T
OR 0.06
p 7.0e-126
N 321,047
Large GWAS
European
forced expiratory volume
Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)
Allele T
OR 0.03
p 4.0e-48
N 321,047
Large GWAS
European
chronic obstructive pulmonary disease
Hobbs BD et al. “Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.” Nature Genetics 49(3):426-432 (2017)
Allele T
OR 1.22
p 9.0e-41
N 58,918
Large GWAS
multi-ancestry
Zhou W et al. “Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.” Cell Genomics 2(10):100192 (2022)
Allele T
OR 0.06
p 7.0e-24
N 1,392,366
Meta-analysisLarge GWAS
multi-ancestry
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.05
p 2.0e-22
N 418,504
Major Consortium StudyLarge GWAS
European
Cho MH et al. “Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.” The Lancet. Respiratory Medicine 2(3):214-25 (2014)
Allele T
OR 1.27
p 2.0e-12
N 12,337
Meta-analysisLarge GWAS
multi-ancestry
hip geometry
Faber BG et al. “The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.” Human Molecular Genetics 34(3):207-217 (2025)
Allele T
OR 0.08
p 2.0e-33
N 43,485
Large GWAS
multi-ancestry
FEV/FVC ratio, response to bronchodilator
Lutz SM et al. “A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.” Bmc Genetics 16:138 (2015)
Allele T
OR —
β 0.018
p 1.0e-19
N 13,532
Large GWAS
multi-ancestry
emphysema
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.11
p 2.0e-15
N 438,248
Major Consortium StudyLarge GWAS
European
forced expiratory volume, response to bronchodilator
Lutz SM et al. “A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.” Bmc Genetics 16:138 (2015)
Allele T
OR —
β 0.072
p 4.0e-14
N 13,532
Large GWAS
multi-ancestry
emphysema imaging measurement
Cho MH et al. “A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes.” American Journal of Respiratory and Critical Care Medicine 192(5):559-69 (2015)
Allele T
OR 0.12
p 2.0e-12
N 12,031
Large GWAS
multi-ancestry
emphysema pattern measurement
Boueiz A et al. “Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.” American Journal of Respiratory and Critical Care Medicine 195(6):757-771 (2017)
Allele T
OR —
β 0.090
p 2.0e-11
N 11,532
Large GWAS
multi-ancestry
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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