rs13222543
This is a intron variant variant in the ZCWPW1 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
androsterone sulfate-to-4-androsten-3beta,17beta-diol disulfate 2 ratio
Shin SY et al. “An atlas of genetic influences on human blood metabolites.” Nature Genetics 46(6):543-550 (2014)
Allele T
OR —
β 0.490
p 4.0e-104
N 5,555
Large GWAS
European
androsterone sulfate measurement
Shin SY et al. “An atlas of genetic influences on human blood metabolites.” Nature Genetics 46(6):543-550 (2014)
Allele T
OR —
β 0.477
p 7.0e-74
N 7,785
Large GWAS
European
epiandrosterone sulfate measurement
Shin SY et al. “An atlas of genetic influences on human blood metabolites.” Nature Genetics 46(6):543-550 (2014)
Allele T
OR —
β 0.347
p 3.0e-47
N 7,769
Large GWAS
European
5alpha-androstan-3beta,17beta-diol disulfate measurement
Shin SY et al. “An atlas of genetic influences on human blood metabolites.” Nature Genetics 46(6):543-550 (2014)
Allele T
OR —
β 0.263
p 1.0e-20
N 7,345
Large GWAS
European
testosterone measurement
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.07
p 1.0e-14
N 322,594
Major Consortium StudyLarge GWAS
multi-ancestry
dehydroepiandrosterone sulphate measurement
Pott J et al. “Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease.” The Journal of Clinical Endocrinology and Metabolism 104(11):5008-5023 (2019)
Allele T
OR 0.31
p 1.0e-8
N 7,659
Large GWAS
European
About ZCWPW1
Enables histone reader activity; methyl-CpG binding activity; and methylated histone binding activity. Predicted to be involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Predicted to act upstream of or within homologous chromosome pairing at meiosis. Predicted to be located in XY body. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
View all ZCWPW1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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