rs13267382

This is a intron variant variant in the LINC00536 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

breast carcinoma

Shu X et al. “Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.” Nature Communications 11(1):1217 (2020)
Allele A
OR 1.04
p 2.0e-12
N 277,932
Large GWAS
multi-ancestry
Michailidou K et al. “Association analysis identifies 65 new breast cancer risk loci.” Nature 551(7678):92-94 (2017)
Allele A
OR 1.03
p 2.0e-11
N 139,274
Large GWAS
multi-ancestry
Michailidou K et al. “Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.” Nature Genetics 47(4):373-80 (2015)
Allele A
OR 1.05
p 2.0e-8
N 33,832
Large GWAS
European
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Research that mentions this SNP (1)

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Gene–environment interactions involving functional variants: Results from the Breast Cancer Association Consortium
AssociationN=58,573Barrdahl M. et al.(2017)· International Journal of Cancer

This large consortium study of 58,573 subjects (26,968 cases, 31,605 controls) assessed gene-environment interactions between 70 breast cancer susceptibility variants and 11 epidemiological risk factors. Four potential interactions were identified with weak evidence (BFDP < 0.80): CFLAR-rs7558475 with current smoking (OR=0.77, p=1.8×10⁻⁴), 5q14-rs7707921 with alcohol consumption (OR=1.36, p=1.9×10⁻⁵), 3p21-rs6796502 with age at menarche (OR=1.26, p=1.8×10⁻⁴), and 8q23-rs13267382 with age at first full-term pregnancy (OR=0.89, p=5.2×10⁻⁴). Overall, no strong gene-environment interactions were detected, suggesting genetic breast cancer risk is not strongly modified by the environmental factors studied.

Traits studied:Breast cancerBreast cancer (ER-negative)Breast cancer (ER-positive)
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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