rs13299349
This is a coding sequence variant variant in the ADAMTSL1 gene.
▶Research that mentions this SNP (1)
▶The association of common polymorphisms in miR-196a2 with waist to hip ratio and miR-1908 with serum lipid and glucoseAssociationN=73,014Mohsen Ghanbari et al.(2015)· Obesity
Two miRNA genetic variants were identified as significantly associated with cardiometabolic phenotypes: rs11614913 in miR-196a2 associated with waist-to-hip ratio (P=1.7e-25), and rs174561 in miR-1908 associated with lipid and glucose traits. Functional analyses revealed these variants affect pre-miRNA processing and regulate target genes involved in fat distribution and lipid metabolism.
About ADAMTSL1
This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
View all ADAMTSL1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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